Today, the NHS announced it has treated its first patient in England with a personalised vaccine against their bowel cancer, in a clinical trial part of NHS England’s new Cancer Vaccine Launch Pad.
As part of the platform, thousands of cancer patients in England are set to gain fast-tracked access to trials of personalised cancer vaccines following the launch of a world-leading NHS trial ‘matchmaking’ service to help find new life-saving treatments.
The vaccines being tested as part of the trials aim to help patients with different types of cancer and, if successfully developed, researched and approved, cancer vaccines could become part of standard care.
“It’s incredibly exciting that patients in England are beginning to access personalised cancer vaccines for bowel cancer,” said Iain Foulkes, executive director of research and innovation at Cancer Research UK.
“This technology pioneers the use of mRNA-based vaccines to sensitise people’s immune system and in turn detect and target cancer at its earliest stages.
“Clinical trials like this are vital in helping more people live longer, better lives, free from the fear of cancer. If successful, the vaccine will be a game changer in preventing the onset or return of bowel cancer.”
A UK first trial
Elliot Phebve, 55, received the developmental jab at University Hospitals Birmingham NHS Foundation Trust, one of several sites taking part in the colorectal cancer vaccine trial sponsored by BioNTech SE.
A higher-education lecturer, Elliot had no cancer symptoms and was diagnosed through a routine health check with his GP.
Following blood tests, he was immediately invited to Manor Hospital in Walsall and triaged to a hospital ward to receive blood transfusions.
A CT scan and a colonoscopy confirmed he had colon cancer and Eliott had surgery to remove the tumour and 30 cm of his large intestine.
He was then referred to the Queen Elizabeth Hospital Birmingham for initial rounds of chemotherapy and to take part in a clinical trial.
“Taking part in this trial tallies with my profession as a lecturer, and as a community-centred person,” he said.
“I want to impact other people’s lives positively and help them realise their potential.
“Through the potential of this trial, if it is successful, it may help thousands, if not millions of people, so they can have hope, and may not experience all I have gone through. I hope this will help other people.”
How do cancer vaccines work?
The vaccine trial Elliot’s taking part in is one of several that will be taking place across the country to treat different types of cancer.
Patients who agree to take part have a sample of their cancer tissue and a blood test taken.
If they meet a clinical trial’s eligibility criteria, they can be referred to their nearest participating NHS site, meaning patients from hospitals across the country will find it easier than ever to take part in groundbreaking research.
The investigational cancer vaccines evaluated in the colorectal cancer trial are based on a molecule called mRNA, the same technology used for the COVID-19 vaccine.
They’re created by analysing a patient’s tumour to identify mutations specific to their own cancer. Using this information, medics can create an individualised cancer vaccine.
The developmental vaccines are designed to induce an immune response that may prevent cancer from returning after surgery by stimulating the patient’s immune system to specifically recognise and potentially destroy any remaining cancer cells.
The investigational cancer vaccines, which are being jointly developed by biopharmaceutical companies BioNTech and Genentech, are still undergoing trials and have not yet been approved by regulators.
